Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.60 |
| ▸ | BCHE | P06276 | 4/20 | 0.60 |
| ▸ | CTSD | P07339 | 13/20 | 0.51 |
| ▸ | BACE2 | Q9Y5Z0 | 12/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938153 | 1.00 | BACE1 (0.60) | BACE1BCHECTSDBACE2 | |
| SCHEMBL3343893 | 0.86 | BACE1 (0.56) | BACE1BCHECTSDBACE2 | |
| SCHEMBL8580373 | 0.85 | BCHE (0.52) | BACE1BCHE | |
| SCHEMBL3343882 | 0.81 | BACE1 (0.55) | BACE1BCHECTSDBACE2 | |
| SCHEMBL8276492 | 0.81 | BACE1 (0.62) | BACE1BCHECTSDBACE2 | |
| SCHEMBL161260 | 0.81 | BACE1 (0.62) | BACE1BCHECTSDBACE2 | |
| SCHEMBL3455222 | 0.81 | BACE1 (0.62) | BACE1BCHECTSDBACE2 | |
| SCHEMBL1937520 | 0.80 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL1937521 | 0.80 | BACE1 (0.47) | BACE1CTSD | |
| Hydrochloric Acid SCHEMBL2499284 | 0.80 | BACE1 (0.61) | BACE1BCHECTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185561-B1 | 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine-6-carboxamide and 2,3,4,5-tetrahydropyrrolo(1,2-a)-diazepine-7-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI AVENTIS (FR) | 2011-06-15 | — | — | EP | disclosed |