Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | JAK1 | P23458 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.46 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19385317 | 0.87 | USP30 (0.71) | USP30JAK2JAK1SMN1; SMN2NPC1 | |
| SCHEMBL19385266 | 0.84 | USP30 (0.59) | USP30JAK2JAK1SMN1; SMN2NPC1 | |
| SCHEMBL16648425 | 0.77 | USP30 (0.50) | USP30JAK2JAK1SMN1; SMN2NPC1 | |
| SCHEMBL16648631 | 0.77 | SMN1; SMN2 (0.57) | USP30JAK2JAK1SMN1; SMN2NPC1 | |
| SCHEMBL19404912 | 0.76 | GRIN2B (0.58) | USP30JAK2JAK1SMN1; SMN2NPC1 | |
| SCHEMBL19400770 | 0.76 | USP30 (0.69) | USP30JAK2JAK1SMN1; SMN2NPC1 | |
| SCHEMBL6391284 | 0.75 | CCNB2 (0.51) | USP30JAK2JAK1SMN1; SMN2NPC1 | |
| SCHEMBL2527780 | 0.75 | SMN1; SMN2 (0.53) | USP30JAK2JAK1SMN1; SMN2NPC1 | |
| SCHEMBL19405091 | 0.74 | SMN1; SMN2 (0.52) | USP30JAK2JAK1SMN1; SMN2NPC1 | |
| SCHEMBL6385152 | 0.74 | CCNA2 (0.51) | USP30JAK2JAK1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3433246-A1 | 1-CYANO-PYRROLIDINE DERIVATIVES AS DBU INHIBITORS | Mission Therapeutics Limited (GB) | 2019-01-30 | — | — | EP | disclosed |
| WO-2017163078-A1 | 1-CYANO-PYRROLIDINE DERIVATIVES AS DBU INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2017-09-28 | — | — | WO | disclosed |