Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20014025 | 0.94 | CRBN (0.51) | CRBNDDB1BRD4STAT3HDAC1 | |
| SCHEMBL20153983 | 0.87 | CRBN (0.50) | CRBNDDB1BRD4STAT3HDAC1 | |
| SCHEMBL19387868 | 0.87 | CRBN (0.53) | CRBNDDB1BRD4STAT3HDAC1 | |
| SCHEMBL19308879 | 0.87 | CRBN (0.54) | CRBNDDB1BRD4STAT3 | |
| SCHEMBL20153975 | 0.85 | CRBN (0.54) | CRBNDDB1BRD4STAT3HDAC1 | |
| SCHEMBL25917968 | 0.85 | CRBN (0.71) | CRBNDDB1STAT3 | |
| SCHEMBL20154048 | 0.85 | CRBN (0.52) | CRBNDDB1BRD4STAT3HDAC1 | |
| SCHEMBL19068590 | 0.85 | CRBN (0.56) | CRBNDDB1BRD4STAT3HDAC1 | |
| SCHEMBL23015941 | 0.84 | CRBN (0.56) | CRBNDDB1BRD4STAT3HDAC1 | |
| SCHEMBL22507992 | 0.84 | CRBN (0.56) | CRBNDDB1BRD4STAT3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9770512-B2 | Methods to induce targeted protein degradation through bifunctional molecules | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-09-26 | — | — | US | disclosed |