Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | PRKACG | P22612 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.42 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3490009 | 0.89 | PIK3CA (0.53) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL1938991 | 0.81 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL571448 | 0.79 | PIK3CG (0.71) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL1939184 | 0.76 | PIK3CA (0.69) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL15803671 | 0.76 | PIK3CA (0.64) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL18618620 | 0.73 | PIK3CA (0.59) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL18616748 | 0.72 | PIK3CA (0.61) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL18113905 | 0.72 | RAF1 (0.38) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL3490772 | 0.72 | PIK3CA (0.53) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL571452 | 0.72 | PIK3CA (0.69) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331537-A1 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010029082-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-03-18 | — | — | WO | disclosed |