Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 19/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.37 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.37 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20749696 | 0.86 | EZH2 (0.51) | EZH2CYP2D6CYP2C19ALDH2EED | |
| SCHEMBL20749746 | 0.83 | EZH2 (0.50) | EZH2CYP2D6CYP2C19ALDH2EED | |
| SCHEMBL20749743 | 0.79 | EZH2 (0.50) | EZH2CYP2D6CYP2C19EEDRBBP4 | |
| SCHEMBL16402804 | 0.79 | EZH2 (0.80) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL16402805 | 0.79 | EZH2 (0.80) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL19390929 | 0.79 | EZH2 (0.46) | EZH2CYP2D6CYP2C19ALDH2EED | |
| SCHEMBL20749728 | 0.77 | EZH2 (0.48) | EZH2CYP2D6CYP2C19EEDRBBP4 | |
| SCHEMBL19390991 | 0.74 | EZH2 (0.37) | EZH2CYP2D6CYP2C19 | |
| SCHEMBL19391171 | 0.74 | EZH2 (0.37) | EZH2CYP2D6CYP2C19ALDH2 | |
| SCHEMBL18573591 | 0.74 | EZH2 (0.68) | EZH2CYP2D6CYP2C19EEDRBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022184-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2017-09-27 | — | — | EP | disclosed |