Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 11/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EED | O75530 | 3/20 | 0.39 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.39 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.39 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19390930 | 0.81 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL15709988 | 0.76 | EZH2 (0.68) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19391013 | 0.73 | EZH2 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL17792537 | 0.73 | EZH2 (0.35) | EZH2LMNASMN1; SMN2 | |
| SCHEMBL16402552 | 0.73 | EZH2 (0.71) | EZH2 | |
| SCHEMBL16402549 | 0.73 | EZH2 (0.71) | EZH2 | |
| SCHEMBL16402547 | 0.70 | EZH2 (0.48) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL25045867 | 0.70 | HPGD (0.60) | JAK2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL17789023 | 0.70 | KDM4E (0.34) | EZH2TSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL19390903 | 0.68 | EZH2 (0.52) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022184-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2017-09-27 | — | — | EP | disclosed |