Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.44 |
| ▸ | EED | O75530 | 4/20 | 0.38 |
| ▸ | RBBP4 | Q09028 | 4/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 4/20 | 0.38 |
| ▸ | RBBP7 | Q16576 | 3/20 | 0.38 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.38 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22517447 | 0.91 | EZH2 (0.45) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12499147 | 0.87 | EZH2 (0.58) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL19958909 | 0.85 | EZH2 (0.44) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684500 | 0.83 | EZH2 (0.58) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL22517687 | 0.81 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12499388 | 0.81 | EZH2 (0.57) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684085 | 0.80 | EZH2 (0.58) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684421 | 0.78 | EZH2 (0.60) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL20170338 | 0.77 | EZH2 (0.63) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL22517513 | 0.77 | EZH2 (0.47) | EZH2EEDRBBP4SUZ12RBBP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681216-B1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | EPIZYME INC (US) | 2017-09-27 | — | — | EP | disclosed |