Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.69 |
| ▸ | ERBB3 | P21860 | 7/20 | 0.69 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.69 |
| ▸ | TEK | Q02763 | 7/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.63 |
| ▸ | KDR | P35968 | 8/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939618 | 0.92 | PDGFRB (0.73) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1942474 | 0.91 | PDGFRB (0.68) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941492 | 0.90 | EGFR (0.71) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941192 | 0.87 | EGFR (0.77) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940529 | 0.86 | PDGFRB (0.69) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940411 | 0.85 | PDGFRB (0.75) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941281 | 0.85 | PDGFRB (0.67) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939633 | 0.84 | PDGFRB (0.73) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941187 | 0.84 | PDGFRB (0.75) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940579 | 0.83 | TEK (0.69) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| US-7271262-B2 | Pyrrolopyrimidine derivatives | PFIZER INC (US) | 2007-09-18 | — | — | US | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |
| EP-1578751-A1 | PYRROLOPYRIMIDINE DERIVATIVES | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20050037999-A1 | Pyrrolopyrimidine derivatives | PFIZER INC | 2005-02-17 | — | — | US | disclosed |
| WO-2004056830-A1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050037999-A1 | Pyrrolopyrimidine derivatives | CCNA1, CCNT1, TP53 | EGFR 2758/4885ERBB2 2738/4885ERBB3 3091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.