Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 5/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.46 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | TEK | Q02763 | 3/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1941311 | 0.94 | PDGFRB (0.70) | PDGFRBNTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL1942117 | 0.92 | PDGFRB (0.65) | PDGFRBNTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL1941086 | 0.92 | PDGFRB (0.75) | PDGFRBNTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL1939912 | 0.91 | PDGFRB (0.62) | PDGFRBNTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL1941408 | 0.91 | PDGFRB (0.68) | PDGFRBNTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL1940188 | 0.90 | PDGFRB (0.59) | PDGFRBNTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL1941573 | 0.90 | PDGFRB (0.67) | PDGFRBNTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL1941745 | 0.90 | PDGFRB (0.67) | PDGFRBNTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL1939745 | 0.90 | PDGFRB (0.66) | PDGFRBNTRK1NTRK2KCNH2NTRK3 | |
| SCHEMBL1940511 | 0.89 | PDGFRB (0.66) | PDGFRBNTRK1NTRK2KCNH2NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |