Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 8/20 | 0.62 |
| ▸ | EGFR | P00533 | 6/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.62 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.62 |
| ▸ | ERBB4 | Q15303 | 5/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.62 |
| ▸ | AURKA | O14965 | 3/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.58 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 12/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.52 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.52 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.52 |
| ▸ | SLK | Q9H2G2 | 4/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.52 |
| ▸ | PLK4 | O00444 | 3/20 | 0.52 |
| ▸ | AXL | P30530 | 3/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939951 | 0.94 | PDGFRB (0.67) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940103 | 0.92 | PDGFRB (0.67) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL4084805 | 0.92 | NTRK1 (0.57) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1941192 | 0.90 | EGFR (0.77) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1941623 | 0.90 | EGFR (0.60) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940724 | 0.89 | EGFR (0.54) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1942915 | 0.89 | PDGFRB (0.61) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1940880 | 0.89 | PDGFRB (0.69) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1939914 | 0.89 | PDGFRB (0.65) | TEKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL1939610 | 0.89 | PDGFRB (0.79) | TEKEGFRERBB2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| EP-1578751-A1 | PYRROLOPYRIMIDINE DERIVATIVES | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056830-A1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |