Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 5/20 | 0.43 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939957 | 0.92 | PDGFRB (0.51) | PDGFRBEIF2AK3PDPK1NTRK1NTRK3 | |
| SCHEMBL1940570 | 0.91 | PDGFRB (0.54) | PDGFRBEIF2AK3PDPK1NTRK1NTRK3 | |
| SCHEMBL1941746 | 0.86 | PDGFRB (0.50) | PDGFRBEIF2AK3PDPK1NTRK1NTRK3 | |
| SCHEMBL1939679 | 0.86 | PDGFRB (0.54) | PDGFRBEIF2AK3PDPK1NTRK1NTRK3 | |
| SCHEMBL1939925 | 0.86 | PDGFRB (0.50) | PDGFRBEIF2AK3PDPK1NTRK1NTRK3 | |
| SCHEMBL1940057 | 0.85 | PDGFRB (0.59) | PDGFRBPDPK1NTRK1NTRK3NTRK2 | |
| SCHEMBL1939658 | 0.84 | PDGFRB (0.51) | PDGFRBEIF2AK3PDPK1NTRK1NTRK3 | |
| SCHEMBL1941376 | 0.84 | EIF2AK3 (0.51) | PDGFRBEIF2AK3PDPK1NTRK1NTRK3 | |
| SCHEMBL1940736 | 0.84 | PDGFRB (0.67) | PDGFRBEIF2AK3PDPK1NTRK1NTRK3 | |
| SCHEMBL1941939 | 0.83 | PDGFRB (0.55) | PDGFRBEIF2AK3PDPK1NTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |