Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD1 | O95696 | 15/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 15/20 | 0.41 |
| ▸ | TAF1 | P21675 | 14/20 | 0.41 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.39 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19404842 | 0.83 | BRD1 (0.61) | BRD1BRPF1TAF1TAF1LCREBBP | |
| SCHEMBL19404853 | 0.80 | BRD1 (0.41) | BRD1BRPF1TAF1TAF1LCREBBP | |
| SCHEMBL19404489 | 0.76 | MEN1 (0.48) | BRD1BRPF1TAF1TAF1LCREBBP | |
| SCHEMBL19404851 | 0.76 | BRD1 (0.65) | BRD1BRPF1TAF1TAF1LCREBBP | |
| SCHEMBL18069181 | 0.76 | KMT2A (0.46) | MEN1KMT2AL3MBTL1POLBTLR9 | |
| SCHEMBL19404605 | 0.74 | TAF1 (0.49) | BRD1BRPF1TAF1TAF1LCREBBP | |
| SCHEMBL19405049 | 0.74 | TAF1 (0.69) | BRD1BRPF1TAF1TAF1LCREBBP | |
| SCHEMBL18069180 | 0.73 | KMT2A (0.48) | BRD4MEN1KMT2AL3MBTL1POLB | |
| SCHEMBL19405041 | 0.73 | BRD1 (0.67) | BRD1BRPF1TAF1BRD4MEN1 | |
| SCHEMBL19404840 | 0.72 | BRD1 (0.46) | BRD1BRPF1TAF1TAF1LCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017162661-A1 | 1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | WO | disclosed |