Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.82 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.82 |
| ▸ | ERBB3 | P21860 | 9/20 | 0.82 |
| ▸ | ERBB4 | Q15303 | 9/20 | 0.82 |
| ▸ | TEK | Q02763 | 9/20 | 0.82 |
| ▸ | KDR | P35968 | 3/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | NEK7 | Q8TDX7 | 6/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939448 | 0.93 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940785 | 0.91 | EGFR (0.83) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940963 | 0.90 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940504 | 0.90 | EGFR (0.97) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941571 | 0.90 | EGFR (0.81) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940155 | 0.90 | EGFR (0.81) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940096 | 0.89 | EGFR (0.80) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941705 | 0.89 | EGFR (0.89) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL27639703 | 0.89 | EGFR (0.84) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941733 | 0.89 | EGFR (0.79) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |