Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.65 |
| ▸ | JAK2 | O60674 | 7/20 | 0.53 |
| ▸ | JAK1 | P23458 | 6/20 | 0.53 |
| ▸ | TTK | P33981 | 3/20 | 0.53 |
| ▸ | TYK2 | P29597 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16812321 | 0.94 | JAK3 (0.66) | JAK3JAK2JAK1TTKTYK2 | |
| SCHEMBL19417616 | 0.93 | JAK3 (0.63) | JAK3JAK2JAK1TTKTYK2 | |
| SCHEMBL15546244 | 0.91 | JAK3 (0.63) | JAK3JAK2JAK1TTKTYK2 | |
| SCHEMBL16782469 | 0.91 | JAK3 (0.77) | JAK3JAK2JAK1TTKTYK2 | |
| SCHEMBL19406496 | 0.91 | JAK3 (0.58) | JAK3JAK2JAK1TTKTYK2 | |
| SCHEMBL15547137 | 0.89 | JAK3 (0.59) | JAK3JAK2JAK1TTKTYK2 | |
| SCHEMBL15547232 | 0.88 | JAK3 (0.63) | JAK3JAK2JAK1TTKTYK2 | |
| SCHEMBL15548500 | 0.88 | JAK3 (0.57) | JAK3JAK2JAK1TTKTYK2 | |
| SCHEMBL15547437 | 0.87 | JAK3 (0.64) | JAK3JAK2JAK1TTKTYK2 | |
| SCHEMBL15546726 | 0.86 | JAK3 (0.62) | JAK3JAK2JAK1TTKTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855451-B1 | HETEROCYCLYL PYRIMIDINE ANALOGUES AS TYK2 INHIBITORS | CELLZOME LTD (GB) | 2017-10-04 | — | — | EP | claimed |