Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.78 |
| ▸ | ERBB3 | P21860 | 9/20 | 0.78 |
| ▸ | ERBB4 | Q15303 | 9/20 | 0.78 |
| ▸ | TEK | Q02763 | 9/20 | 0.78 |
| ▸ | KDR | P35968 | 4/20 | 0.78 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 5/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1941365 | 0.94 | EGFR (0.81) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939343 | 0.93 | EGFR (0.75) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941575 | 0.90 | EGFR (0.87) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939954 | 0.90 | EGFR (0.75) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1942784 | 0.89 | EGFR (0.84) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941005 | 0.89 | EGFR (0.82) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941076 | 0.89 | EGFR (0.79) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940262 | 0.88 | EGFR (0.83) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939939 | 0.88 | EGFR (0.84) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941146 | 0.88 | EGFR (0.75) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |