Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 5/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940711 | 0.96 | MAPT (0.48) | MAPTKMT2ACRHBPCRHR2KDR | |
| SCHEMBL1941600 | 0.93 | KDR (0.49) | MAPTKMT2ACRHBPCRHR2KDR | |
| SCHEMBL3931741 | 0.91 | MAPT (0.48) | MAPTKMT2ACRHBPCRHR2KDR | |
| SCHEMBL1940765 | 0.91 | KDR (0.50) | MAPTKMT2ACRHBPCRHR2KDR | |
| SCHEMBL1941133 | 0.89 | MAPT (0.53) | MAPTKMT2ACRHBPCRHR2KDR | |
| SCHEMBL1939946 | 0.88 | MAPT (0.51) | MAPTKMT2ACRHBPCRHR2KDR | |
| SCHEMBL3922954 | 0.88 | KDR (0.49) | KMT2AKDRKDM4ETDP1ALDH1A1 | |
| SCHEMBL1940549 | 0.88 | KDR (0.51) | MAPTKMT2ACRHBPCRHR2KDR | |
| SCHEMBL3935942 | 0.88 | KDR (0.47) | MAPTKMT2ACRHBPCRHR2KDR | |
| SCHEMBL1943221 | 0.88 | MAPT (0.49) | MAPTKMT2ACRHBPCRHR2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1717229-B1 | NOVEL CYCLIC COMPOUND HAVING 4-PYRIDYLALKYLTHIO GROUP HAVING (UN)SUBSTITUTED AMINO INTRODUCED THEREIN | SANTEN PHARMACEUTICAL CO LTD (JP) | 2011-06-15 | — | — | EP | claimed |
| US-7544703-B2 | Cyclic compound having 4-pyridylalkylthio group having substituted or unsubstituted amino group introduced therein | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | claimed |