Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.63 |
| ▸ | ERBB3 | P21860 | 9/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 9/20 | 0.63 |
| ▸ | TEK | Q02763 | 8/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 6/20 | 0.49 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940390 | 0.91 | EGFR (0.68) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940714 | 0.87 | EGFR (0.54) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941521 | 0.86 | EGFR (0.73) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941218 | 0.83 | EGFR (0.70) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939527 | 0.83 | EGFR (0.62) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941067 | 0.82 | EGFR (0.75) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940246 | 0.81 | EGFR (0.75) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941181 | 0.79 | EGFR (0.74) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941449 | 0.78 | EGFR (0.71) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941336 | 0.78 | EGFR (0.66) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |