Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.80 |
| ▸ | MPC2 | O95563 | 2/20 | 0.80 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | RXRA | P19793 | 2/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mitoglitazone SCHEMBL18541503 | 0.89 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL622605 | 0.89 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL18541482 | 0.89 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL18538169 | 0.89 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL2221702 | 0.88 | PPARG (0.98) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL2221427 | 0.85 | PPARG (0.92) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| SCHEMBL11929116 | 0.80 | PPARG (0.76) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| SCHEMBL14413449 | 0.80 | PPARG (0.83) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL2219522 | 0.80 | PPARG (0.70) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL2224095 | 0.80 | PPARG (0.70) | PPARGMPC2CYP2C8CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2902026-B1 | THIAZOLIDINEDIONE ANALOGUES FOR THE TREATMENT OF METABOLIC INFLAMMATION MEDIATED DISEASE | METABOLIC SOLUTIONS DEV CO LLC (US) | 2017-10-04 | — | — | EP | disclosed |