Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.52 |
| ▸ | JAK2 | O60674 | 13/20 | 0.52 |
| ▸ | JAK1 | P23458 | 10/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15546366 | 0.92 | JAK3 (0.61) | JAK3JAK2JAK1 | |
| SCHEMBL16782601 | 0.86 | JAK3 (0.61) | JAK3JAK2JAK1 | |
| SCHEMBL15547988 | 0.84 | JAK3 (0.59) | JAK3JAK2JAK1 | |
| SCHEMBL16782442 | 0.83 | JAK3 (0.50) | JAK3JAK2JAK1 | |
| SCHEMBL15547424 | 0.83 | JAK3 (0.52) | JAK3JAK2JAK1 | |
| SCHEMBL16782587 | 0.82 | JAK3 (0.57) | JAK3JAK2JAK1 | |
| SCHEMBL15547290 | 0.80 | JAK3 (0.56) | JAK3JAK2JAK1 | |
| SCHEMBL15559205 | 0.79 | JAK3 (0.59) | JAK3JAK2JAK1 | |
| SCHEMBL15548553 | 0.77 | JAK3 (0.54) | JAK3JAK2JAK1 | |
| SCHEMBL15547421 | 0.76 | JAK3 (0.58) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855451-B1 | HETEROCYCLYL PYRIMIDINE ANALOGUES AS TYK2 INHIBITORS | CELLZOME LTD (GB) | 2017-10-04 | — | — | EP | disclosed |