Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.43 |
| ▸ | GSK3A | P49840 | 14/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19849273 | 0.75 | SLC22A12 (0.40) | GSK3BGSK3AMAPT | |
| SCHEMBL19849337 | 0.75 | RPS6KA3 (0.39) | GSK3BGSK3AALDH1A1 | |
| SCHEMBL16702417 | 0.73 | GSK3B (0.70) | GSK3BGSK3AMAPT | |
| SCHEMBL3151005 | 0.67 | GSK3B (0.50) | GSK3BGSK3AMAPTALDH1A1ALOX15 | |
| SCHEMBL3151007 | 0.67 | GSK3B (0.50) | GSK3BGSK3AMAPTALDH1A1ALOX15 | |
| SCHEMBL10514041 | 0.66 | SMN1; SMN2 (0.47) | ALDH1A1 | |
| SCHEMBL16702419 | 0.66 | GSK3B (0.57) | GSK3BGSK3AMAPTALDH1A1ALOX15 | |
| SCHEMBL24134560 | 0.64 | RPS6KA3 (0.46) | GSK3BGSK3AMAPTALDH1A1ALOX15 | |
| SCHEMBL12097403 | 0.64 | KDM4C (0.49) | GSK3BGSK3AMAPTALDH1A1ALOX15 | |
| SCHEMBL20190114 | 0.64 | GSK3A (0.73) | GSK3BGSK3AMAPTALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066093-B9 | GSK-3 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-02-07 | — | — | EP | disclosed |
| EP-3066093-B1 | GSK-3 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-10-04 | — | — | EP | disclosed |