SCHEMBL19418011

SCHEMBL19418011

C[C@@H]1C/C=C/CC/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2CO1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 4/20 0.67
MAPT P10636 3/20 0.39
HSP90AA1 P07900 2/20 0.39
ACLY P53396 2/20 0.39
RAB9A P51151 2/20 0.39
NPSR1 Q6W5P4 2/20 0.39
GAA P10253 1/20 0.39
NLRP3 Q96P20 1/20 0.39
CBR1 P16152 1/20 0.39
PTGS2 P35354 1/20 0.39
FTO Q9C0B1 1/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
KMT2A Q03164 1/20 0.39
F13A1 P00488 1/20 0.39
TGM2 P21980 1/20 0.39
MKNK2 Q9HBH9 1/20 0.36
VCP P55072 1/20 0.34
STAT6 P42226 8/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pochonin D SCHEMBL4513578 0.81 HSP90AB1 (1.00) HSP90AB1MAPTHSP90AA1ACLYRAB9A
Pochonin D SCHEMBL2683508 0.81 HSP90AB1 (1.00) HSP90AB1MAPTHSP90AA1ACLYRAB9A
Pochonin D SCHEMBL669590 0.81 HSP90AB1 (1.00) HSP90AB1MAPTHSP90AA1ACLYRAB9A
Pochonin D SCHEMBL10150436 0.81 HSP90AB1 (1.00) HSP90AB1MAPTHSP90AA1ACLYRAB9A
Pochonin D SCHEMBL2683506 0.81 HSP90AB1 (1.00) HSP90AB1MAPTHSP90AA1ACLYRAB9A
SCHEMBL14293422 0.79 HSP90AB1 (0.80) HSP90AB1MAPTHSP90AA1ACLYRAB9A
SCHEMBL10150141 0.72 HSP90AB1 (0.84) HSP90AB1MAPTHSP90AA1ACLYRAB9A
SCHEMBL10150003 0.71 HSP90AB1 (0.75) HSP90AB1MAPTHSP90AA1ACLYRAB9A
SCHEMBL19418434 0.70 HSP90AB1 (0.59) HSP90AB1MAPTHSP90AA1ACLYRAB9A
SCHEMBL10150456 0.70 HSP90AB1 (0.78) HSP90AB1MAPTHSP90AA1ACLYRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2136799-B1 MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 UNIV STRASBOURG (FR) 2017-10-04 EP disclosed