SCHEMBL19418015

SCHEMBL19418015

C=CCC/C=C/C(=O)Cc1c(Cl)c(O)cc(O)c1C(=O)O[C@H](C)CC=C

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 9/20 0.32
HSP90B1 P14625 6/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10150467 0.87
SCHEMBL12142562 0.80
SCHEMBL10150442 0.80
SCHEMBL10150439 0.80
SCHEMBL10150459 0.80
SCHEMBL10150454 0.77 HSP90AA1 (0.33) HSP90AA1HSP90B1
SCHEMBL12142572 0.77
SCHEMBL19418369 0.77 HSP90AA1 (0.39) HSP90AA1HSP90B1
SCHEMBL12142520 0.76
SCHEMBL10150629 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2136799-B1 MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 UNIV STRASBOURG (FR) 2017-10-04 EP disclosed