Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584516 | 0.95 | MAPT (0.53) | GAAEPHX1RAB9AMAPTPOLB | |
| SCHEMBL1413349 | 0.93 | GAA (0.56) | GAAEPHX1RAB9AMAPTPOLB | |
| SCHEMBL30882289 | 0.93 | GAA (0.56) | GAAEPHX1RAB9AMAPTPOLB | |
| SCHEMBL2931808 | 0.91 | GAA (0.46) | GAAEPHX1RAB9AMAPTPOLB | |
| SCHEMBL28127425 | 0.91 | POLB (0.47) | GAAEPHX1RAB9AMAPTPOLB | |
| Hydrochloric Acid SCHEMBL5447331 | 0.90 | GAA (0.45) | GAAEPHX1RAB9AMAPTPOLB | |
| 4-Aminophenol SCHEMBL2890947 | 0.85 | GAA (0.53) | GAAEPHX1RAB9AMAPTPOLB | |
| SCHEMBL11526739 | 0.83 | MAPT (0.63) | GAARAB9AMAPTPOLBLMNA | |
| SCHEMBL20684088 | 0.83 | POLB (0.42) | GAAEPHX1RAB9AMAPTPOLB | |
| SCHEMBL21174667 | 0.82 | MAPT (0.60) | GAAEPHX1RAB9AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925757-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2017-10-04 | — | — | EP | disclosed |