Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | CBR1 | P16152 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10150365 | 1.00 | HSP90AB1 (0.64) | HSP90AB1HSP90AA1MAPTGAARAB9A | |
| SCHEMBL12253188 | 0.88 | HSP90AB1 (0.61) | HSP90AB1HSP90AA1MAPTGAARAB9A | |
| SCHEMBL12252590 | 0.88 | HSP90AB1 (0.61) | HSP90AB1HSP90AA1MAPTGAARAB9A | |
| SCHEMBL10150274 | 0.87 | MKNK2 (0.50) | HSP90AB1MAPTRAB9ANPSR1MKNK2 | |
| SCHEMBL10150219 | 0.87 | MKNK2 (0.50) | HSP90AB1MAPTRAB9ANPSR1MKNK2 | |
| SCHEMBL12252449 | 0.86 | HSP90AB1 (0.59) | HSP90AB1HSP90AA1MAPTGAARAB9A | |
| SCHEMBL10150408 | 0.86 | HSP90AB1 (0.59) | HSP90AB1HSP90AA1MAPTGAARAB9A | |
| SCHEMBL10150814 | 0.86 | HSP90AB1 (0.59) | HSP90AB1HSP90AA1MAPTGAARAB9A | |
| SCHEMBL12252505 | 0.86 | HSP90AB1 (0.43) | HSP90AB1HSP90AA1MAPTGAARAB9A | |
| SCHEMBL12252497 | 0.86 | HSP90AB1 (0.43) | HSP90AB1HSP90AA1MAPTGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136799-B1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | UNIV STRASBOURG (FR) | 2017-10-04 | — | — | EP | disclosed |