Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 6/20 | 0.37 |
| ▸ | KIT | P10721 | 4/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.37 |
| ▸ | FLT4 | P35916 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.37 |
| ▸ | FLT1 | P17948 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | F13A1 | P00488 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10150573 | 0.89 | HSP90AB1 (0.69) | HSP90AB1MKNK2FLT3KITPDGFRA | |
| SCHEMBL10150686 | 0.80 | HSP90AB1 (0.41) | HSP90AB1MKNK2FLT3MAP3K7MKNK1 | |
| SCHEMBL10150687 | 0.80 | HSP90AB1 (0.41) | HSP90AB1MKNK2MAOA | |
| SCHEMBL868888 | 0.80 | HSP90AB1 (0.59) | HSP90AB1MKNK2FLT3KITPDGFRA | |
| SCHEMBL868889 | 0.80 | HSP90AB1 (0.59) | HSP90AB1MKNK2FLT3KITPDGFRA | |
| SCHEMBL10187334 | 0.77 | HSP90AB1 (0.39) | HSP90AB1MKNK2MKNK1MAOANR2C2 | |
| SCHEMBL19418408 | 0.77 | HSP90AB1 (0.52) | HSP90AB1MKNK2FLT3KITPDGFRA | |
| SCHEMBL10150110 | 0.75 | HSP90AB1 (0.71) | HSP90AB1MKNK2FLT3KITPDGFRA | |
| SCHEMBL10150095 | 0.74 | HSP90AB1 (0.69) | HSP90AB1MKNK2FLT3KITPDGFRA | |
| SCHEMBL10150699 | 0.72 | HSP90AB1 (0.65) | HSP90AB1MKNK2FLT3KITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136799-B1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | UNIV STRASBOURG (FR) | 2017-10-04 | — | — | EP | disclosed |