Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.45 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.45 |
| ▸ | TEK | Q02763 | 2/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | ITGA1 | P56199 | 3/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1941175 | 0.92 | BTK (0.59) | BTKPDGFRBEGFRERBB2ERBB3 | |
| SCHEMBL1941126 | 0.91 | BTK (0.58) | BTKPDGFRBEGFRERBB2ERBB3 | |
| SCHEMBL1941592 | 0.91 | BTK (0.69) | BTKEGFRERBB2ERBB3TEK | |
| SCHEMBL1941090 | 0.91 | BTK (0.55) | BTKPDGFRBEGFRERBB2ERBB3 | |
| SCHEMBL1940319 | 0.90 | BTK (0.59) | BTKEGFRERBB2ERBB3TEK | |
| SCHEMBL1939646 | 0.90 | BTK (0.59) | BTKEGFRERBB2ERBB3TEK | |
| SCHEMBL1940259 | 0.90 | BTK (0.53) | BTKPDGFRBEGFRERBB2ERBB3 | |
| SCHEMBL1940038 | 0.89 | BTK (0.55) | BTKEGFRERBB2ERBB3TEK | |
| SCHEMBL1940086 | 0.88 | BTK (0.56) | BTKCYP19A1BRAFTNNI3KMEN1 | |
| SCHEMBL1941241 | 0.88 | BTK (0.50) | BTKPDGFRBEGFRERBB2ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| US-7271262-B2 | Pyrrolopyrimidine derivatives | PFIZER INC (US) | 2007-09-18 | — | — | US | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |
| EP-1578751-A1 | PYRROLOPYRIMIDINE DERIVATIVES | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056830-A1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |