Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22912716 | 0.91 | SCN9A (0.47) | SCN9ASCN1ASCN4ASCN7ASCN5A | |
| SCHEMBL19411381 | 0.85 | SCN9A (0.54) | SCN9A | |
| SCHEMBL19411371 | 0.83 | SCN9A (0.54) | SCN9ASCN7ASCN5A | |
| SCHEMBL19411416 | 0.83 | SCN9A (0.50) | SCN9A | |
| SCHEMBL19430740 | 0.81 | SCN9A (0.68) | SCN9ASCN7ASCN5A | |
| SCHEMBL22912689 | 0.79 | SCN9A (0.50) | SCN9ASCN5ASCN3A | |
| SCHEMBL20910582 | 0.73 | SCN9A (0.42) | SCN9ASCN1ASCN4ASCN7ASCN5A | |
| SCHEMBL19431000 | 0.73 | SCN9A (0.42) | SCN9ASCN1ASCN4ASCN7ASCN5A | |
| SCHEMBL16240142 | 0.70 | SCN9A (0.61) | SCN9ASCN5A | |
| SCHEMBL17423019 | 0.67 | SCN9A (0.82) | SCN9ASCN1ASCN7ASCN5ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3854782-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2021-07-28 | — | — | EP | disclosed |
| EP-3436432-B1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2017172802-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-10-05 | — | — | WO | disclosed |