Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1945446 | 0.92 | POLB (0.49) | POLBPDE4BPDE7AKMT2A | |
| SCHEMBL1946608 | 0.92 | POLB (0.48) | POLBPDE4BPDE7AKMT2A | |
| SCHEMBL1944592 | 0.91 | POLB (0.51) | POLBPDE4BPDE7AKMT2AADORA1 | |
| SCHEMBL1942105 | 0.91 | POLB (0.47) | POLBPDE4BPDE7AKMT2A | |
| SCHEMBL1944462 | 0.91 | POLB (0.47) | POLBPDE4BPDE7AKMT2A | |
| SCHEMBL1944198 | 0.91 | POLB (0.48) | POLBPDE4BPDE7A | |
| SCHEMBL1945937 | 0.89 | POLB (0.47) | POLBPDE4BPDE7AKMT2A | |
| SCHEMBL1945939 | 0.89 | POLB (0.47) | POLBPDE4BKMT2A | |
| SCHEMBL582833 | 0.87 | POLB (0.48) | POLBPDE4BPDE7AKMT2A | |
| SCHEMBL582547 | 0.86 | POLB (0.51) | POLBPDE4BPDE7AKMT2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130403-A1 | PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2011-06-02 | — | — | US | claimed |
| US-20110130403-A1 | PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130403-A1 | PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE3B, PDE4B | POLB 1829/4885PDE4B 3/4885PDE7A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.