Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 11/20 | 0.61 |
| ▸ | TYRO3 | Q06418 | 11/20 | 0.61 |
| ▸ | AXL | P30530 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19429534 | 0.82 | TYRO3 (0.62) | MERTKTYRO3AXL | |
| SCHEMBL19429550 | 0.81 | MERTK (0.65) | MERTKTYRO3AXL | |
| SCHEMBL26711743 | 0.81 | MERTK (0.62) | MERTKTYRO3AXL | |
| SCHEMBL19377753 | 0.79 | MERTK (0.61) | MERTKTYRO3AXL | |
| SCHEMBL19377602 | 0.76 | MERTK (1.00) | MERTKTYRO3AXL | |
| SCHEMBL19429633 | 0.76 | TYRO3 (1.00) | MERTKTYRO3AXL | |
| SCHEMBL19377643 | 0.76 | MERTK (0.76) | MERTKTYRO3AXL | |
| SCHEMBL19398128 | 0.75 | TYRO3 (1.00) | MERTKTYRO3AXL | |
| SCHEMBL19403879 | 0.75 | TYRO3 (1.00) | MERTKTYRO3AXL | |
| SCHEMBL19377713 | 0.75 | MERTK (1.00) | MERTKTYRO3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2017172596-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION (US) | 2017-10-05 | — | — | WO | disclosed |