Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 11/20 | 0.87 |
| ▸ | TYRO3 | Q06418 | 12/20 | 0.74 |
| ▸ | AXL | P30530 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377579 | 0.93 | MERTK (1.00) | MERTKTYRO3AXL | |
| SCHEMBL19429747 | 0.90 | TYRO3 (0.74) | MERTKTYRO3AXL | |
| SCHEMBL19377706 | 0.85 | TYRO3 (1.00) | MERTKTYRO3AXL | |
| SCHEMBL19377604 | 0.84 | MERTK (1.00) | MERTKTYRO3AXL | |
| SCHEMBL19377573 | 0.83 | MERTK (0.84) | MERTKTYRO3AXL | |
| SCHEMBL19377618 | 0.83 | MERTK (0.85) | MERTKTYRO3AXL | |
| SCHEMBL19377553 | 0.83 | MERTK (0.83) | MERTKTYRO3AXL | |
| SCHEMBL19377581 | 0.82 | MERTK (0.83) | MERTKTYRO3AXL | |
| SCHEMBL29625538 | 0.82 | MERTK (1.00) | MERTKTYRO3AXL | |
| SCHEMBL19377571 | 0.82 | MERTK (1.00) | MERTKTYRO3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2017172596-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION (US) | 2017-10-05 | — | — | WO | disclosed |