Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLI1 | Q01543 | 5/20 | 0.77 |
| ▸ | EWSR1 | Q01844 | 5/20 | 0.77 |
| ▸ | ERG | P11308 | 1/20 | 0.77 |
| ▸ | ETV1 | P50549 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 9/20 | 0.47 |
| ▸ | MMP8 | P22894 | 9/20 | 0.47 |
| ▸ | MMP2 | P08253 | 8/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CBX7 | O95931 | 2/20 | 0.40 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.40 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.40 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19829782 | 0.87 | FLI1 (1.00) | FLI1EWSR1ERGETV1ALDH1A1 | |
| SCHEMBL29399443 | 0.87 | FLI1 (1.00) | FLI1EWSR1ERGETV1ALDH1A1 | |
| SCHEMBL19829781 | 0.87 | FLI1 (1.00) | FLI1EWSR1ERGETV1ALDH1A1 | |
| SCHEMBL3486735 | 0.87 | FLI1 (1.00) | FLI1EWSR1ERGETV1ALDH1A1 | |
| SCHEMBL17679856 | 0.87 | FLI1 (0.73) | FLI1EWSR1ERGETV1ALDH1A1 | |
| SCHEMBL29810788 | 0.87 | FLI1 (0.73) | FLI1EWSR1ERGETV1ALDH1A1 | |
| SCHEMBL17679855 | 0.87 | FLI1 (0.73) | FLI1EWSR1ERGETV1ALDH1A1 | |
| SCHEMBL17669239 | 0.87 | FLI1 (0.73) | FLI1EWSR1ERGETV1ALDH1A1 | |
| SCHEMBL19424045 | 0.86 | FLI1 (0.73) | FLI1EWSR1ERGETV1ALDH1A1 | |
| SCHEMBL15337268 | 0.85 | FLI1 (0.78) | FLI1EWSR1ERGETV1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017172368-A1 | INDOLINE ANALOGS AND USES THEREOF | Oncternal Therapeutics, Inc. (US) | 2017-10-05 | — | — | WO | disclosed |