SCHEMBL194342

SCHEMBL194342

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nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MPI P34949 1/20 0.55
PGD P52209 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mannose 6-Phosphate SCHEMBL5789525 0.85 MPI (0.75) MPIPGD
Mannose 6-Phosphate SCHEMBL6599 0.85 MPI (0.75) MPIPGD
Mannose 6-Phosphate SCHEMBL8488 0.85 MPI (0.75) MPIPGD
Mannose 6-Phosphate SCHEMBL9739836 0.85 MPI (0.75) MPIPGD
Mannose 6-Phosphate SCHEMBL1874195 0.85 MPI (0.75) MPIPGD
Mannose 6-Phosphate SCHEMBL9736768 0.85 MPI (0.75) MPIPGD
Mannose 6-Phosphate SCHEMBL2319337 0.85 MPI (0.75) MPIPGD
Mannose 6-Phosphate SCHEMBL9738212 0.85 MPI (0.75) MPIPGD
Mannose 6-Phosphate SCHEMBL20798006 0.85 MPI (0.75) MPIPGD
Mannose 6-Phosphate SCHEMBL5790782 0.85 MPI (0.75) MPIPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2481743-B1 LPA receptor agonists and antagonists and methods of use UNIV TENNESSEE RES FOUND (US) 2017-03-22 EP disclosed
EP-2433946-B1 LPA receptor agonists and antagonists and methods of use UNIV TENNESSEE RES FOUNDATION (US) 2016-04-20 EP disclosed
EP-2481743-A1 LPA receptor agonists and antagonists and methods of use UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2012-08-01 EP disclosed
US-20120135967-A1 LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE MILLER DUANE D (US) 2012-05-31 US disclosed
EP-2433946-A1 LPA receptor agonists and antagonists and methods of use University of Tennessee Research Foundation (US) 2012-03-28 EP disclosed
EP-1678096-B1 LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE UNIV TENNESSEE RES FOUNDATION (US) 2012-01-04 EP disclosed
US-7947665-B2 lysophosphatidic acid receptor modulator; thiophosphoric acid O-[7-(4-octyl-phenyl)-heptyl] ester; treating cancer, wounds, skin disorders and apoptosis; preserving or restoring function in a cell, tissue or organ; culturing cells; preserving organ or tissue function; and enhancing cell proliferation MILLER DUANE D 2011-05-24 US disclosed
US-20080090783-A1 lysophosphatidic acid receptor modulator; thiophosphoric acid O-[7-(4-octyl-phenyl)-heptyl] ester; treating cancer, wounds, skin disorders and apoptosis; preserving or restoring function in a cell, tissue or organ; culturing cells; preserving organ or tissue function; and enhancing cell proliferation MILLER DUANE D 2008-04-17 US disclosed
US-7217704-B2 LPA receptor agonists and antagonists and methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2007-05-15 US disclosed
EP-1678096-A4 LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE UNIV TENNESSEE RES CORP (US) 2007-04-18 EP disclosed
EP-1678096-A2 LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) 2006-07-12 EP disclosed
US-20060009507-A1 Thio-phosphoric and -phosphorous acid derivatives; treating cancer, wounds, skin disorders and apoptosis; preserving or restoring function in a cell, tissue or organ; culturing cells; preserving organ or tissue function; and enhancing cell proliferation UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2006-01-12 US disclosed
WO-2005032494-A2 LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2005-04-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060009507-A1 Thio-phosphoric and -phosphorous acid derivatives; treating cancer, wounds, skin disorders and apoptosis; preserving or restoring function in a cell, tissue or organ; culturing cells; preserving organ or tissue function; and enhancing cell proliferation LPAR1, LPAR6, LPAR2 MPI 2078/4885PGD 1991/4885
US-20120135967-A1 LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE LPAR1, LPAR2, LPAR4 MPI 3236/4885PGD 2922/4885
US-20080090783-A1 lysophosphatidic acid receptor modulator; thiophosphoric acid O-[7-(4-octyl-phenyl)-heptyl] ester; treating cancer, wounds, skin disorders and apoptosis; preserving or restoring function in a cell, tissue or organ; culturing cells; preserving organ or tissue function; and enhancing cell proliferation LPAR1, LPAR4, LPAR2 MPI 2194/4885PGD 1652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.