Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.71 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885778 | 0.91 | PDE9A (0.68) | PDE9APDE1C | |
| SCHEMBL7884418 | 0.89 | PDE9A (0.66) | PDE9APDE1C | |
| SCHEMBL1427637 | 0.88 | PDE9A (0.67) | PDE9APDE1C | |
| SCHEMBL7880512 | 0.87 | PDE9A (0.67) | PDE9APDE1C | |
| SCHEMBL19434437 | 0.87 | PDE9A (0.67) | PDE9APDE1C | |
| SCHEMBL7876160 | 0.87 | PDE9A (0.74) | PDE9APDE1C | |
| SCHEMBL7882921 | 0.87 | PDE9A (0.74) | PDE9APDE1C | |
| SCHEMBL7888328 | 0.87 | PDE9A (0.82) | PDE9APDE1C | |
| SCHEMBL7882627 | 0.87 | PDE9A (0.82) | PDE9APDE1C | |
| SCHEMBL7880524 | 0.85 | PDE9A (0.64) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071549-B | PDE1 inhibitors | H.隆德贝克有限公司 | 2021-11-30 | — | — | CN | disclosed |
| EP-3442975-B1 | 1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AND 1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]PYRIDIN-4-ONES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2020-07-29 | — | — | EP | disclosed |
| US-20200102316-A1 | 1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AND 1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]PYRIDIN-4-ONES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2020-04-02 | — | — | US | disclosed |
| US-10538525-B2 | 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2020-01-21 | — | — | US | disclosed |
| US-20190194204-A1 | 1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AND 1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]PYRIDIN-4-ONES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2019-06-27 | — | — | US | disclosed |
| US-20170291901-A1 | 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2017-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200102316-A1 | 1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AND 1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]PYRIDIN-4-ONES AS PDE1 INHIBITORS | PDE4A, PDE4B, PDE12 | PDE9A 13/4885PDE1C 15/4885 |
| US-20190194204-A1 | 1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONES AND 1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]PYRIDIN-4-ONES AS PDE1 INHIBITORS | PDE4A, PDE4B, PDE12 | PDE9A 13/4885PDE1C 15/4885 |
| US-10538525-B2 | 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 inhibitors | PDE4A, PDE4B, PDE12 | PDE9A 13/4885PDE1C 15/4885 |
| US-20170291901-A1 | 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 Inhibitors | PDE4A, PDE4B, PDE12 | PDE9A 13/4885PDE1C 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.