Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 7/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2601662 | 1.00 | TSHR (0.40) | TSHRAPPMEN1KMT2A | |
| SCHEMBL12974426 | 1.00 | TSHR (0.40) | TSHRAPPMEN1KMT2A | |
| SCHEMBL13139306 | 1.00 | TSHR (0.40) | TSHRAPPMEN1KMT2A | |
| SCHEMBL17868379 | 1.00 | TSHR (0.40) | TSHRAPPMEN1KMT2A | |
| SCHEMBL6726747 | 1.00 | TSHR (0.40) | TSHRAPPMEN1KMT2A | |
| SCHEMBL2628203 | 0.95 | — | — | |
| SCHEMBL1513715 | 0.95 | — | — | |
| SCHEMBL31324014 | 0.86 | TSHR (0.48) | TSHRMEN1KMT2A | |
| SCHEMBL15803984 | 0.86 | TSHR (0.48) | TSHRMEN1KMT2A | |
| SCHEMBL22589673 | 0.86 | TSHR (0.48) | TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400992-B1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELLING | GENENTECH INC (US) | 2015-07-22 | — | — | EP | disclosed |
| US-8865122-B2 | Methods and compositions for protein labelling | GENENTECH, INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-20130216475-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELLING | GENENTECH, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-8435488-B2 | Methods and compositions for protein labelling | GENENTECH, INC. (US) | 2013-05-07 | — | — | US | disclosed |
| EP-2400992-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELLING | Genentech, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099273-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELLING | GENENTECH, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
| US-20100221176-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELLING | GENENTECH, INC. | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100221176-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELLING | RAB5IF, RPS27A, PSMA6 | TSHR 2895/4885APP 320/4885MEN1 2279/4885 |
| US-20130216475-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELLING | RAB5IF, RPS27A, PSMA6 | TSHR 2895/4885APP 320/4885MEN1 2279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.