Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1946070 | 0.93 | PDE4B (0.48) | PDE4BPDE5APDE4D | |
| SCHEMBL1945370 | 0.92 | PDE4B (0.57) | PDE4BPDE5A | |
| SCHEMBL1943973 | 0.89 | PDE4B (0.48) | PDE4BPDE4D | |
| SCHEMBL1943242 | 0.87 | PDE4B (0.47) | PDE4BPDE4D | |
| SCHEMBL1946335 | 0.85 | PDE4B (0.50) | PDE4BPDE4D | |
| SCHEMBL1942662 | 0.85 | PDE4B (0.52) | PDE4BPDE4D | |
| SCHEMBL1944882 | 0.85 | PDE4B (0.51) | PDE4B | |
| SCHEMBL1943098 | 0.84 | PDE4B (0.51) | PDE4BPDE4D | |
| SCHEMBL1943605 | 0.83 | PDE4B (0.55) | PDE4BPDE4D | |
| SCHEMBL1944806 | 0.82 | PDE4B (0.44) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130403-A1 | PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2011-06-02 | — | — | US | claimed |
| US-20110130403-A1 | PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130403-A1 | PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE3B, PDE4B | PDE4B 3/4885PDE5A 6/4885PDE4D 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.