Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | INSRR | P14616 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.48 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18589178 | 0.93 | ALK (0.64) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL18589101 | 0.91 | ALK (0.68) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL18589138 | 0.90 | ALK (0.80) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL19441027 | 0.89 | ALK (0.56) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL18589045 | 0.89 | ALK (0.56) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL19441025 | 0.88 | ALK (0.68) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL18589097 | 0.88 | ALK (0.82) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL18589202 | 0.86 | ALK (0.66) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL18589070 | 0.84 | ALK (0.78) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL17054322 | 0.83 | ALK (0.80) | ALKDAPK3INSRINSRRLTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783539-B2 | Indoloquinolone compounds as anaplastic lymphoma kinase (ALK) inhibitors | JIANGSU ASCENTAGE BIOMED DEVELOPMENT INC. (CN) | 2017-10-10 | — | — | US | disclosed |