Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4104877 | 0.90 | MAPK14 (0.43) | MAPK14JAK2NTRK1CA2CCNK | |
| SCHEMBL4306726 | 0.81 | MAPK14 (0.45) | MAPK14JAK2NTRK1CA2CCNK | |
| SCHEMBL2878758 | 0.80 | MAPK14 (0.44) | MAPK14JAK2NTRK1CA2CCNK | |
| SCHEMBL4100658 | 0.78 | MAPK14 (0.43) | MAPK14JAK2NTRK1CA2CCNK | |
| SCHEMBL7594473 | 0.77 | MAPK14 (0.48) | MAPK14JAK2NTRK1CA2CCNK | |
| SCHEMBL19560079 | 0.76 | MAPK14 (0.52) | MAPK14 | |
| SCHEMBL9774733 | 0.75 | MAPK14 (0.53) | MAPK14CA2 | |
| SCHEMBL9774729 | 0.75 | MAPK14 (0.53) | MAPK14CA2 | |
| SCHEMBL18812935 | 0.74 | JAK2 (0.56) | MAPK14JAK2NTRK1CCNKCDK12 | |
| SCHEMBL10387224 | 0.72 | MAPK14 (0.50) | MAPK14CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782415-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2017-10-10 | — | — | US | disclosed |