Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.82 |
| ▸ | JAK3 | P52333 | 8/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | LCK | P06239 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17857075 | 0.90 | BTK (1.00) | BTKJAK3JAK2JAK1TYK2 | |
| SCHEMBL19441958 | 0.89 | BTK (0.81) | BTKJAK3JAK2JAK1TYK2 | |
| SCHEMBL18411303 | 0.84 | BTK (0.89) | BTKJAK3JAK2JAK1TYK2 | |
| SCHEMBL18396633 | 0.79 | BTK (0.81) | BTKJAK3JAK2JAK1TYK2 | |
| SCHEMBL19441970 | 0.79 | BTK (0.75) | BTKJAK3JAK2JAK1TYK2 | |
| SCHEMBL17857095 | 0.79 | BTK (0.83) | BTKJAK3JAK2JAK1TYK2 | |
| SCHEMBL17857074 | 0.78 | BTK (1.00) | BTKJAK3JAK2JAK1TYK2 | |
| SCHEMBL17857072 | 0.77 | BTK (1.00) | BTKJAK3JAK2JAK1TYK2 | |
| SCHEMBL18411236 | 0.74 | BTK (0.67) | BTKJAK3JAK2JAK1KDR | |
| SCHEMBL21081492 | 0.72 | EGFR (0.52) | BTKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783504-B2 | Kinase inhibitors for the treatment of disease | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-10-10 | — | — | US | disclosed |