Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | CTSC | P53634 | 3/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | JAK3 | P52333 | 5/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | BLK | P51451 | 2/20 | 0.48 |
| ▸ | ITK | Q08881 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | TXK | P42681 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17856985 | 0.92 | BTK (0.68) | BTKLCKFGFR1CTSCEGFR | |
| SCHEMBL17837341 | 0.85 | BTK (0.79) | BTKFGFR1CTSCEGFRJAK3 | |
| SCHEMBL16371246 | 0.83 | BTK (0.62) | BTKLCKFGFR1CTSCFGFR3 | |
| SCHEMBL19227454 | 0.83 | LCK (0.62) | BTKLCKFGFR1FGFR3CYP3A4 | |
| SCHEMBL17857009 | 0.82 | BTK (0.67) | BTKFGFR1CTSCFGFR3EGFR | |
| SCHEMBL16370525 | 0.81 | BTK (0.58) | BTKLCKFGFR1CTSCFGFR3 | |
| SCHEMBL30537280 | 0.81 | BTK (0.59) | BTKLCKFGFR1CTSCFGFR3 | |
| SCHEMBL17837342 | 0.81 | BTK (0.81) | BTKFGFR1CTSCEGFRJAK3 | |
| SCHEMBL17857033 | 0.80 | BTK (0.66) | BTKFGFR1CTSCEGFRJAK3 | |
| SCHEMBL17857037 | 0.80 | BTK (0.65) | BTKFGFR1CTSCEGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783504-B2 | Kinase inhibitors for the treatment of disease | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-10-10 | — | — | US | disclosed |