Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.47 |
| ▸ | CDK4 | P11802 | 12/20 | 0.46 |
| ▸ | CCND1 | P24385 | 12/20 | 0.46 |
| ▸ | CCND2 | P30279 | 7/20 | 0.46 |
| ▸ | CCND3 | P30281 | 7/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1393033 | 0.87 | CDK4 (0.48) | BTKMAP4K1CDK4CCND1CCND2 | |
| SCHEMBL29742006 | 0.87 | CDK4 (0.48) | BTKMAP4K1CDK4CCND1CCND2 | |
| SCHEMBL10289462 | 0.83 | CDK4 (0.48) | MAP4K1CDK4CCND1CCND2CCND3 | |
| SCHEMBL10256584 | 0.78 | CCND3 (0.48) | MAP4K1CDK4CCND1CCND2CCND3 | |
| Hydrochloric Acid SCHEMBL1393269 | 0.77 | CDK2 (0.47) | MAP4K1CDK4CCND1CCND2CCND3 | |
| SCHEMBL708026 | 0.76 | BTK (0.52) | BTKMAP4K1CDK4CCND1CCND2 | |
| SCHEMBL14926244 | 0.76 | BTK (0.44) | BTKMAP4K1CDK4CCND1CCND2 | |
| SCHEMBL14915792 | 0.75 | CDK4 (0.45) | BTKMAP4K1CDK4CCND1CCND2 | |
| SCHEMBL14915902 | 0.75 | CDK4 (0.45) | BTKMAP4K1CDK4CCND1CCND2 | |
| SCHEMBL14915791 | 0.75 | CDK4 (0.45) | BTKMAP4K1CDK4CCND1CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782405-B2 | Heteroaryl pyridone and aza-pyrodine compounds | GENENTECH, INC. (US) | 2017-10-10 | — | — | US | disclosed |