Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GLP1R | P43220 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19464316 | 0.83 | TP53 (0.43) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL16136239 | 0.80 | KDM4E (0.57) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL19442750 | 0.78 | CDK4 (0.47) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL19442824 | 0.78 | ATM (0.46) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL20027130 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL19442778 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL19442780 | 0.75 | TP53 (0.45) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL19442781 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL16136170 | 0.71 | KDM4E (0.53) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL16136040 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1GAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783529-B2 | Pyridazinone compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2017-10-10 | — | — | US | disclosed |