Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 18/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1944184 | 0.90 | POLB (0.46) | POLBPDE4BPDE3BPDE7APDE3A | |
| SCHEMBL1944198 | 0.89 | POLB (0.48) | POLBPDE4BPDE3BPDE7APDE3A | |
| SCHEMBL1944188 | 0.89 | POLB (0.47) | POLBPDE4BPDE7A | |
| SCHEMBL1944043 | 0.88 | POLB (0.47) | POLBPDE4BPDE3BPDE7APDE3A | |
| SCHEMBL1944592 | 0.88 | POLB (0.51) | POLBPDE4BPDE7A | |
| SCHEMBL582913 | 0.86 | POLB (0.46) | POLBPDE4BPDE3BPDE7APDE3A | |
| SCHEMBL1944628 | 0.86 | POLB (0.46) | POLBPDE4B | |
| SCHEMBL582195 | 0.86 | POLB (0.45) | POLBPDE4BPDE3BPDE7APDE3A | |
| SCHEMBL583007 | 0.86 | POLB (0.45) | POLBPDE4BPDE3BPDE7APDE3A | |
| SCHEMBL582863 | 0.85 | POLB (0.45) | POLBPDE4BPDE3BPDE7APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130403-A1 | PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2011-06-02 | — | — | US | claimed |
| US-20110130403-A1 | PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130403-A1 | PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE3B, PDE4B | POLB 1829/4885PDE4B 3/4885PDE3B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.