Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.68 |
| ▸ | MTOR | P42345 | 9/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.68 |
| ▸ | PIK3C2B | O00750 | 3/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | PRKACG | P22612 | 1/20 | 0.56 |
| ▸ | PRKACB | P22694 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16912825 | 0.91 | PIK3CA (0.69) | PIK3CAPIK3CGMTORPIK3CDPIK3C2B | |
| SCHEMBL16919687 | 0.86 | PIK3CA (0.68) | PIK3CAPIK3CGMTORPIK3CDPIK3C2B | |
| SCHEMBL16920278 | 0.86 | PIK3CA (0.68) | PIK3CAPIK3CGMTORPIK3CDPIK3C2B | |
| SCHEMBL19445390 | 0.85 | PIK3CA (0.61) | PIK3CAPIK3CGMTORPIK3CDPIK3C2B | |
| SCHEMBL16912793 | 0.85 | PIK3CA (0.72) | PIK3CAPIK3CGMTORPIK3CDPIK3C2B | |
| SCHEMBL16919695 | 0.84 | PIK3CA (0.66) | PIK3CAPIK3CGMTORPIK3CDPIK3C2B | |
| SCHEMBL16919691 | 0.84 | PIK3CA (0.66) | PIK3CAPIK3CGMTORPIK3CDPIK3C2B | |
| SCHEMBL19445261 | 0.84 | PIK3CA (0.66) | PIK3CAPIK3CGMTORPIK3CDPIK3C2B | |
| SCHEMBL19445356 | 0.84 | PIK3CA (0.68) | PIK3CAPIK3CGMTORPIK3CDPIK3C2B | |
| SCHEMBL16912837 | 0.84 | PIK3CA (0.68) | PIK3CAPIK3CGMTORPIK3CDPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885297-B1 | TRISUBSTITUTED PYRIDO[3,2-D]PYRIMIDINES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTICAL USES | CENTRE NAT DE LA RECH SCIENT (C N R S ) (FR) | 2017-10-11 | — | — | EP | disclosed |