Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 18/20 | 0.89 |
| ▸ | PRKDC | P78527 | 1/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL611166 | 0.94 | PIK3CG (1.00) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10174790 | 0.91 | PIK3CG (0.90) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142804 | 0.91 | PIK3CG (0.86) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10174592 | 0.90 | PIK3CG (0.79) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10174445 | 0.87 | PIK3CG (0.86) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142313 | 0.87 | PIK3CG (0.89) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10174656 | 0.86 | PIK3CG (0.80) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142454 | 0.86 | PIK3CG (1.00) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10142949 | 0.85 | PIK3CG (0.81) | PIK3CGPRKDCPIK3CA | |
| SCHEMBL10174594 | 0.85 | PIK3CG (0.71) | PIK3CGPRKDCPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516417-B1 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | VERTEX PHARMA (US) | 2017-10-11 | — | — | EP | disclosed |