Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 7/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17782285 | 1.00 | NR1H2 (0.45) | NR1H2NR1H3RIPK1GRM5GPR119 | |
| SCHEMBL17782283 | 1.00 | NR1H2 (0.45) | NR1H2NR1H3RIPK1GRM5GPR119 | |
| SCHEMBL18995315 | 0.87 | NR1H2 (0.43) | NR1H2NR1H3RIPK1GRM5GPR119 | |
| SCHEMBL16401244 | 0.84 | USP30 (0.39) | RIPK1 | |
| SCHEMBL26984189 | 0.84 | NR1H2 (0.46) | NR1H2NR1H3RIPK1GPR119RXRA | |
| SCHEMBL26984170 | 0.83 | NR1H2 (0.45) | NR1H2NR1H3RIPK1GPR119RXRA | |
| SCHEMBL2706442 | 0.79 | NR1H2 (0.50) | NR1H2NR1H3RIPK1GPR119RXRA | |
| SCHEMBL642698 | 0.79 | NR1H2 (0.50) | NR1H2NR1H3RIPK1GPR119RXRA | |
| SCHEMBL29115999 | 0.79 | NR1H2 (0.50) | NR1H2NR1H3RIPK1GPR119RXRA | |
| SCHEMBL26994047 | 0.79 | NR1H2 (0.43) | NR1H2NR1H3RIPK1GPR119MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022192-B1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | NOVARTIS AG (CH) | 2017-10-11 | — | — | EP | disclosed |