Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 12/20 | 0.63 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FRK | P42685 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | LDHB | P07195 | 1/20 | 0.44 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13340416 | 1.00 | CSF1R (0.63) | CSF1RBRAFRETPDGFRBKIT | |
| SCHEMBL13340266 | 0.88 | CSF1R (0.61) | CSF1RBRAFRETPDGFRBKIT | |
| SCHEMBL19447192 | 0.88 | CSF1R (0.61) | CSF1RBRAFRETPDGFRBKIT | |
| SCHEMBL19447228 | 0.86 | CSF1R (0.65) | CSF1RBRAFRETPDGFRBKIT | |
| SCHEMBL13340410 | 0.86 | CSF1R (0.65) | CSF1RBRAFRETPDGFRBKIT | |
| SCHEMBL13340280 | 0.83 | CSF1R (0.63) | CSF1RBRAF | |
| SCHEMBL13340424 | 0.83 | CSF1R (0.57) | CSF1RBRAFRETPDGFRBKIT | |
| SCHEMBL13340090 | 0.82 | CSF1R (0.63) | CSF1RBRAFRETPDGFRBKIT | |
| SCHEMBL19447205 | 0.82 | CSF1R (0.63) | CSF1RBRAFRETPDGFRBKIT | |
| SCHEMBL19447285 | 0.81 | BRAF (0.51) | CSF1RBRAFATRLDHALDHB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848610-B1 | Inhibitors of kinase activity | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2017-10-11 | — | — | EP | disclosed |