Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 13/20 | 0.65 |
| ▸ | BRAF | P15056 | 2/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | FRK | P42685 | 1/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13340409 | 1.00 | CSF1R (0.65) | CSF1RBRAFFGFR1DDR2SRC | |
| SCHEMBL3475477 | 0.92 | CSF1R (0.64) | CSF1RBRAFSRCPDGFRBPDGFRA | |
| SCHEMBL3475478 | 0.92 | CSF1R (0.64) | CSF1RBRAFSRCPDGFRBPDGFRA | |
| SCHEMBL13340272 | 0.89 | CSF1R (0.65) | CSF1RBRAFFGFR1DDR2SRC | |
| SCHEMBL3475141 | 0.87 | CSF1R (0.71) | CSF1RSRCPDGFRBPDGFRARET | |
| SCHEMBL3475138 | 0.87 | CSF1R (0.71) | CSF1RSRCPDGFRBPDGFRARET | |
| SCHEMBL13340286 | 0.86 | CSF1R (0.63) | CSF1RBRAFSRCPDGFRBPDGFRA | |
| SCHEMBL13340431 | 0.86 | CSF1R (0.61) | CSF1RBRAFSRCPDGFRBPDGFRA | |
| SCHEMBL18023931 | 0.85 | ABL1 (0.64) | CSF1RBRAFDDR2SRCPDGFRB | |
| SCHEMBL17954640 | 0.84 | CSF1R (0.73) | CSF1RSRCPDGFRBPDGFRARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848610-B1 | Inhibitors of kinase activity | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2017-10-11 | — | — | EP | disclosed |