SCHEMBL19447307

SCHEMBL19447307

Cc1cn2nc(C3CCCCN3C(=O)c3cccc(F)c3C)cc2nc1N1CCC(N)C1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 16/20 0.40
HCRTR2 O43614 16/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15073045 1.00 HCRTR1 (0.40) HCRTR1HCRTR2
SCHEMBL2737741 0.94 HCRTR1 (0.38) HCRTR1HCRTR2
SCHEMBL2738210 0.94 GRM5 (0.39) HCRTR1HCRTR2
SCHEMBL19447419 0.93 HCRTR1 (0.37) HCRTR1HCRTR2
SCHEMBL19447294 0.93 HCRTR1 (0.37) HCRTR1HCRTR2
SCHEMBL15073067 0.93 HCRTR1 (0.37) HCRTR1HCRTR2
SCHEMBL15073052 0.92 HCRTR1 (0.37) HCRTR1HCRTR2
SCHEMBL15077200 0.92 HCRTR1 (0.40) HCRTR1HCRTR2
SCHEMBL2737703 0.92 HCRTR1 (0.40) HCRTR1HCRTR2
SCHEMBL19447601 0.91 GRM5 (0.36) HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2794611-B1 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS GILEAD SCIENCES INC (US) 2017-10-11 EP disclosed