Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 11/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 11/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19447486 | 0.90 | HCRTR1 (0.35) | HCRTR1HCRTR2 | |
| SCHEMBL15077207 | 0.90 | HCRTR1 (0.37) | HCRTR1HCRTR2GRM5 | |
| SCHEMBL15073052 | 0.89 | HCRTR1 (0.37) | HCRTR1HCRTR2GRM5 | |
| SCHEMBL19447524 | 0.89 | HCRTR1 (0.36) | HCRTR1HCRTR2 | |
| SCHEMBL15077068 | 0.89 | HCRTR1 (0.35) | HCRTR1HCRTR2 | |
| SCHEMBL15072899 | 0.89 | HCRTR1 (0.35) | HCRTR1HCRTR2JAK2TYK2GRM5 | |
| SCHEMBL19447330 | 0.88 | GRM5 (0.37) | HCRTR1HCRTR2GRM5 | |
| SCHEMBL19447381 | 0.87 | HCRTR1 (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL19447333 | 0.86 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL19447619 | 0.86 | HCRTR1 (0.37) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794611-B1 | PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS | GILEAD SCIENCES INC (US) | 2017-10-11 | — | — | EP | disclosed |