SCHEMBL19448952

SCHEMBL19448952

CCCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(C=O)cc(OC)c21

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
STING1 Q86WV6 19/20 0.75
ENPP1 P22413 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19449082 0.95 STING1 (0.76) STING1
SCHEMBL19448933 0.89 STING1 (0.61) STING1
SCHEMBL23637098 0.88 STING1 (0.69) STING1
SCHEMBL19449025 0.88 STING1 (0.60) STING1
SCHEMBL19457908 0.88 STING1 (0.63) STING1
SCHEMBL20889137 0.87 STING1 (0.67) STING1ENPP1
SCHEMBL23637166 0.86 STING1 (0.64) STING1
SCHEMBL23637226 0.86 STING1 (0.61) STING1
SCHEMBL19448935 0.86 STING1 (0.66) STING1ENPP1
SCHEMBL19451835 0.86 STING1 (0.63) STING1ENPP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3848366-A1 HIGHLY ACTIVE STING PROTEIN AGONIST COMPOUND Adlai Nortye Biopharma Co., Ltd. (CN) 2021-07-14 EP disclosed
WO-2017175156-A1 HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-10-12 WO disclosed